The usage of Promethazine with Codeine Oral Remedy in patients with acute or critical bronchial asthma in an unmonitored location or inside the absence of resuscitative equipment is contraindicated [seeCONTRAINDICATIONS (4)]. Opioid analgesics and antitussives, including codeine, one of the active components in Promethazine with Codeine Oral Answer